Paranoid psychosis after a single parenteral dose of indomethacin administered for headache diagnosis: A case and review of the literature
Background: Indomethacin is a non-steroidal anti-inflammatory used to diagnose and treat hemicrania continua and paroxysmal hemicrania. Treatment can be complicated by gastrointestinal adverse effects; less commonly reported are idiosyncratic neuropsychiatric adverse effects with indomethacin. Metho...
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SAGE Publishing,
2024-02-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_db50bb229a86408c99bcc63bea0a38bd | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Nazia Karsan |e author |
| 700 | 1 | 0 | |a Ray Pyari Bose |e author |
| 700 | 1 | 0 | |a Peter J Goadsby |e author |
| 245 | 0 | 0 | |a Paranoid psychosis after a single parenteral dose of indomethacin administered for headache diagnosis: A case and review of the literature |
| 260 | |b SAGE Publishing, |c 2024-02-01T00:00:00Z. | ||
| 500 | |a 2515-8163 | ||
| 500 | |a 10.1177/25158163241230685 | ||
| 520 | |a Background: Indomethacin is a non-steroidal anti-inflammatory used to diagnose and treat hemicrania continua and paroxysmal hemicrania. Treatment can be complicated by gastrointestinal adverse effects; less commonly reported are idiosyncratic neuropsychiatric adverse effects with indomethacin. Methods: A 50-year-old male with lateralized brief attacks of headache associated with cranial autonomic symptoms was administered a single 200 mg dose of intramuscular indomethacin. Within an hour, he developed acute psychosis, with paranoid delusions and verbal and physical aggression lasting 5 h, followed by recovery to baseline. We used search terms "indomethacin psychosis," "indomethacin psychiatric," "indomethacin side effects," "non-steroidal anti-inflammatory psychosis," and "non-steroidal anti-inflammatory psychiatric" within PubMed to identify previous reports and literature in this area. Results: Neuropsychiatric adverse effects of indomethacin have been reported since 1965 in a dose-dependent manner, usually with oral courses. They may be more common in the elderly, postpartum women and postoperative patients. Conclusion: Neuropsychiatric adverse effects should be considered in headache medicine, particularly in at-risk groups when indomethacin is administered. Patients, particularly those at highest risk, should be counseled about the risk of neuropsychiatric side effects on indomethacin which may be dose-dependent and are generally reversible on stopping the drug. | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Neurosciences. Biological psychiatry. Neuropsychiatry | ||
| 690 | |a RC321-571 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Cephalalgia Reports, Vol 7 (2024) | |
| 787 | 0 | |n https://doi.org/10.1177/25158163241230685 | |
| 787 | 0 | |n https://doaj.org/toc/2515-8163 | |
| 856 | 4 | 1 | |u https://doaj.org/article/db50bb229a86408c99bcc63bea0a38bd |z Connect to this object online. |