Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.

• Main Authors: Elliot W Kim (Author), Rosane M B Teles (Author), Salem Haile (Author), Philip T Liu (Author), Robert L Modlin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The immune system depends on effector pathways to eliminate invading pathogens from the host in vivo. Macrophages (MΦ) of the innate immune system are armed with vitamin D-dependent antimicrobial responses to kill intracellular microbes. However, how the physiological levels of vitamin D...