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Acute kidney injury in adults aged 60 years or older hospitalized with COVID-19 and association with mortality

Objective: To analyze the presence of acute kidney injury (AKI) in hospitalized older patients with COVID-19 and its association with hospital mortality. Methods: This was a retrospective observational case-control study of patients over 60 years of age hospitalized from April 01, 2020, to April 30,...

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Main Authors: Ingrid Ardisson Colodete (Author), Caroline Delboni Nascimento (Author), Sarah de Jesus Francisco (Author), Manoela Morgado Horta Barros (Author), Júlia Magalhães Monteiro (Author), Júlia Andrade Rodrigues Alves (Author), Caroline Maffei Spinassé (Author), Caroline Tessinari Pupim (Author), Julia Almenara Ribeiro Vieira (Author), Renato Lirio Morelato (Author)
Format: Book
Published: Brazilian Society of Geriatrics and Gerontology, 2024-11-01T00:00:00Z.
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Summary:Objective: To analyze the presence of acute kidney injury (AKI) in hospitalized older patients with COVID-19 and its association with hospital mortality. Methods: This was a retrospective observational case-control study of patients over 60 years of age hospitalized from April 01, 2020, to April 30, 2021, at a ward or intensive care unit (ICU) dedicated to COVID-19. The severity of AKI was stratified according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Binary logistic regression was used to determine the association of mortality in models with and without adjustment for previous comorbidities as risk factors. Results: Of 897 patients aged 19-107 years hospitalized with COVID-19, 398 aged ≥ 60 years were included. AKI was observed in 220 patients (55.27%), with stages 1, 2, and 3 in 25.87%, 5.52%, and 23.86%, respectively. Dialysis was required in 73 patients with AKI (33.18%), most of them were at stage 3 (91.89%). Fifty-four patients on dialysis died (73.97%). Increased AKI severity was associated with mortality even after removing the influence of associated risk factors (odds ratios 1.78, 2.35, and 3.51 at stages 1, 2, and 3, respectively). Conclusion: AKI was highly common in patients aged 60 years or older hospitalized with COVID-19, and its severity showed a progressive association with hospital mortality.
Item Description:2447-2123
10.53886/gga.e0000152_EN

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