Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives

• Hauptverfasser: Suriyawut Kulatee (VerfasserIn), Pisanu Toochinda (VerfasserIn), Anotai Suksangpanomrung (VerfasserIn), Luckhana Lawtrakul (VerfasserIn)
• Format: Buch
• Veröffentlicht: MDPI AG, 2017-11-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Point mutations in Plasmodium falciparum dihydrofolate reductase (pfDHFR), especially the double mutant variant (A16V + S108T), led to ineffective inhibiting by cycloguanil (Cyc). Cycloguanil derivatives showed good inhibiting properties against wild-type and mutant pfDHFR with an inhibition constan...