Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives
Point mutations in Plasmodium falciparum dihydrofolate reductase (pfDHFR), especially the double mutant variant (A16V + S108T), led to ineffective inhibiting by cycloguanil (Cyc). Cycloguanil derivatives showed good inhibiting properties against wild-type and mutant pfDHFR with an inhibition constan...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2017-11-01T00:00:00Z.
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