Population Pharmacokinetics of Phosphocreatine and Its Metabolite Creatine in Children With Myocarditis

• Main Authors: Huan He (Author), Meng Zhang (Author), Li-bo Zhao (Author), Ning Sun (Author), Yi Zhang (Author), Yue Yuan (Author), Xiao-ling Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: This study aimed to develop a parent-metabolite joint population pharmacokinetic model to characterize the pharmacokinetic (PK) profile for phosphocreatine (PCr) and its metabolite creatine (Cr) in children with myocarditis and to use this model to study the PK profile of different dosing...