ASSESSMENT OF PTX3 LEVELS IN GINGIVAL CREVICULAR FLUID AND GINGIVAL INFLAMMATION DURING TOOTH ERUPTION IN CHILDREN WITH TYPE 1 DIABETES VERSUS CHILDREN WITHOUT SYSTEMIC CONDITIONS

• Main Authors: Roxana Onea (Author), Flavia Mirela Nicolae (Author), Dora Maria Popescu (Author), Marilena Bataiosu (Author), Camelia Fiera Maglaviceanu (Author), Claudiu Ionele (Author), Carmen Niculescu (Author), Mihail Virgil Boldeanu (Author), Adina Turcu-Știolică (Author), Allma Pitru (Author)
• Format: Book
• Published: Romanian Society of Oral Rehabilitation, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2066-7000; 2601-4661
• Keywords: type 1 diabetes mellitus; tooth eruption; ptx3; gingival inflammation; Dentistry; RK1-715
• Source: Romanian Journal of Oral Rehabilitation, Vol 15, Iss 4, Pp 286-298 (2023)

Background: The specialized literature has reported the presence of inflammatory periodontal changes among pediatric patients diagnosed with type 1 diabetes mellitus (T1DM). The aim of our study is to evaluate Pentraxin 3 (PTX3) levels in gingival crevicular fluid (GCF) of erupting teeth and gingival inflammation in children with and without T1DM. Methods: A total of 43 patients were included in this study, aged between 6-12 years, with 23 having a diagnosis of T1DM and 20 healthy patients. All subjects underwent periodontal examination, the values of the Silness-Loe Plaque Index (PI) and Gingival Index (GI) were recorded and GCF was collected from an erupting tooth. Results: Significant differences exist between the two groups regarding glycosylated hemoglobin (HbA1c), PTX3 levels, and GI values. In patients with T1DM, a strong significant correlation exists between PTX3 and HbA1c levels, as well as between PTX3 and PI and GI values. Additionally, a strong negative correlation was found between age and PI and GI values. There is also a strong positive correlation between HbA1c and PI and GI values. Conclusions: PTX3 levels in GCF and the gingival inflammation are significantly higher in children with diabetes during dental eruption, under conditions of comparable plaque accumulation.