Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels

The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppresse...

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Main Authors: A. L. Pukhalsky (Author), M. S. Bliacher (Author), A. V. Danilina (Author), E. A. Kalashnikova (Author), T. K. Lopatina (Author), I. M. Fedorova (Author)
Format: Book
Published: Hindawi Limited, 1996-01-01T00:00:00Z.
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Summary:The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. On the other hand, serum levels of TNF were markedly increased over a period of 3 weeks. It was also demonstrated that the postvaccinal cytokine production disturbances may be corrected by pretreatment with a new synthetic hexapeptid (Imunofan®). It is possible that the imunofan treatment could prevent some postvaccinal complications.
Item Description:0962-9351
1466-1861
10.1155/S0962935196000592