Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels
The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppresse...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Hindawi Limited,
1996-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. On the other hand, serum levels of TNF were markedly increased over a period of 3 weeks. It was also demonstrated that the postvaccinal cytokine production disturbances may be corrected by pretreatment with a new synthetic hexapeptid (Imunofan®). It is possible that the imunofan treatment could prevent some postvaccinal complications. |
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| Item Description: | 0962-9351 1466-1861 10.1155/S0962935196000592 |