Lappaol F, an anticancer agent, inhibits YAP via transcriptional and post-translational regulation

• Main Authors: Xiao Li (Author), Yi-Ying Lin (Author), Jia-Yi Tan (Author), Kang-Lun Liu (Author), Xiao-Ling Shen (Author), Ying-Jie Hu (Author), Rui-Yi Yang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumour cell growth by inducing cell cycle arrest. However, its underlying anticancer mechanism remains unclear. Objective The effects of LAF on the Hippo-Yes-associated protein (YAP) signalling pathway, which p...