PXR variants: the impact on drug metabolism and therapeutic responses
The pregnane X receptor (PXR) plays an important and diverse role in mediating xenobiotic induction of drug-metabolizing enzymes and transporters. Several protein isoforms of PXR exist, and they have differential transcriptional activity upon target genes; transcript variants 3 (PXR3) and 4 (PXR4) d...
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| Main Authors: | , |
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| Format: | Book |
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Elsevier,
2016-09-01T00:00:00Z.
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