Quercetin enhances survival and axonal regeneration of motoneurons after spinal root avulsion and reimplantation: experiments in a rat model of brachial plexus avulsion

• Main Authors: Yanfeng Huang (Author), Xie Zhang (Author), Qionghui Huang (Author), Yaoxing Dou (Author), Chang Qu (Author), Qingqing Xu (Author), Qiuju Yuan (Author), Yan-Fang Xian (Author), Zhi-Xiu Lin (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Highlights • Quercetin (QCN) promotes motoneuron survival and accelerates axonal regeneration after brachial plexus root avulsion/re-implantation in rats. • QCN improves motor function recovery of the forelimb. • QCN exhibits neuroprotective effects via inhibiting neuroinflammation and upregulating the neurotrophins. • QCN alleviates the avulsion-induced oxidative damage in rats. • QCN inhibits the avulsion-induced neuronal apoptosis in rats. • QCN modulates Nrf2/HO-1 and neurotrophin/Akt/MAPK signaling pathways.

Item Description

10.1186/s41232-022-00245-3
1880-8190