Antidepressant, neuropharmacological activity and mode of action of theaflavin-3-gallate in in vitro and in vivo models of depression

• Main Authors: Ying Wang (Author), Jing Chen (Author), Jing Wang (Author), Xin Guo (Author), Ning Wang (Author), Jie Yuan (Author)
• Format: Book
• Published: Bangladesh Pharmacological Society, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein the antidepressant-like effect of theaflavin-3-gallate, a plant polyphenolic compound in 1-methyl-4-phenyl pyridinium-induced neuronal injury in N2a cells used as an in vitro model of depression as well as in vivo. The results from MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium b...