Pan-Genome Plasticity and Virulence Factors: A Natural Treasure Trove for <i>Acinetobacter baumannii</i>

• Main Authors: Theodoros Karampatakis (Author), Katerina Tsergouli (Author), Payam Behzadi (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antibiotics13030257; 2079-6382
• Keywords: <i>Acinetobacter baumannii</i>; genome; plasticity; virulence factors; molecular pathogenicity; Therapeutics. Pharmacology; RM1-950
• Source: Antibiotics, Vol 13, Iss 3, p 257 (2024)

<i>Acinetobacter baumannii</i> is a Gram-negative pathogen responsible for a variety of community- and hospital-acquired infections. It is recognized as a life-threatening pathogen among hospitalized individuals and, in particular, immunocompromised patients in many countries. <i>A. baumannii,</i> as a member of the ESKAPE group, encompasses high genomic plasticity and simultaneously is predisposed to receive and exchange the mobile genetic elements (MGEs) through horizontal genetic transfer (HGT). Indeed, <i>A. baumannii</i> is a treasure trove that contains a high number of virulence factors. In accordance with these unique pathogenic characteristics of <i>A. baumannii</i>, the authors aim to discuss the natural treasure trove of pan-genome and virulence factors pertaining to this bacterial monster and try to highlight the reasons why this bacterium is a great concern in the global public health system.