A case-control study of serum and tissue catalase among morphological variants of vitiligo
Background: Role of oxidative stress in the pathogenesis of vitiligo. Aim: Estimation of serum and tissue catalase levels in morphological variants of vitiligo. Settings and Design: A prospective case-control study was conducted in the outpatient department of Dermatology in Safdarjung hospital. Mat...
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| Main Authors: | , , |
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| Format: | Book |
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Wolters Kluwer Medknow Publications,
2023-01-01T00:00:00Z.
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| Summary: | Background: Role of oxidative stress in the pathogenesis of vitiligo. Aim: Estimation of serum and tissue catalase levels in morphological variants of vitiligo. Settings and Design: A prospective case-control study was conducted in the outpatient department of Dermatology in Safdarjung hospital. Materials and Methods: We estimated levels of serum and tissue catalase in 30 vitiligo patients and 30 matched healthy controls. Statistical Analysis: The data analysis was done in Statistical Package for Social Sciences (SPSS) version 21.0. Normality of data was tested by Kolmogorov-Smirnov test. Results: Serum and tissue catalase was lower in vitiligo patients than controls. Serum catalase was lowest in vulgaris type, whereas in the acrofacial type had lowest tissue catalase levels. Conclusion: Vitiligo patients have a generalized oxidative stress functioning at a higher pace as seen with decreased serum and tissue CAT which can well be taken as a marker of active disease and they can be helped with topical pseudoCAT preparations. |
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| Item Description: | 0019-5154 1998-3611 10.4103/ijd.ijd_946_20 |