<i>Myrtus communis</i> L. Essential Oil Exhibits Antiviral Activity against Coronaviruses

• প্রধান লেখক: Dar-Yin Li (Author), Matthew G. Donadu (Author), Taylor Shue (Author), Georgios Dangas (Author), Antonis Athanasiadis (Author), Shuiyun Lan (Author), Xin Wen (Author), Basem Battah (Author), Stefania Zanetti (Author), Vittorio Mazzarello (Author), Stefan G. Sarafianos (Author), Marco Ferrari (Author), Eleftherios Michailidis (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2024-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.
• Notes: 10.3390/ph17091189; 1424-8247
• Keywords: Myrtus; antiviral drugs; HCoV-229E; HCoV-OC43; SARS-CoV-2; essential oil; Medicine; R; Pharmacy and materia medica; RS1-441
• Source: Pharmaceuticals, Vol 17, Iss 9, p 1189 (2024)

Human coronaviruses are a continuous threat to the human population and have limited antiviral treatments, and the recent COVID-19 pandemic sparked interest in finding new antiviral strategies, such as natural products, to combat emerging coronaviruses. Rapid efforts in the scientific community to identify effective antiviral agents for coronaviruses remain a focus to minimize mortalities and global setbacks. In this study, an essential oil derived from <i>Myrtus communis</i> L. (MEO) is effective against HCoV-229E and HCoV-OC43 virus infections in comparison to two FDA-approved drugs, Remdesivir and Nirmatrelvir. Gas-chromatography and mass spectrometry were used to identify the chemical composition of MEO. Slight antioxidant activity was observed in MEO, indicating a role in oxidative stress. A dose-response curve measuring the EC₅₀ indicates a high potency against HCoV-229E and HCoV-OC43 virus infections on Huh7.5 cells with low cytotoxicity using a PrestoBlue cell viability assay. Our findings demonstrate that MEO exhibits potent antiviral activity against HCoV-229E and HCoV-OC43 on Huh7.5 cells within a low-cytotoxicity range, but not on SARS-CoV-2. Artificial bacterial chromosome plasmids that expressed SARS-CoV-2 used for replicon-to determine viral replication and viral assembly/egress on HEK293T/17 cells-and virus-like particles on Huh7.5-AT cells-to determine viral entry and assembly/egress-showed no antiviral activity with MEO in comparison to Remdesivir. This study reveals the potential effectiveness of MEO as an alternative natural remedy to treat human coronaviruses and a potential antiviral agent for future coronavirus infections.