Electrochemical behavior of paclitaxel and its determination at glassy carbon electrode
The electrochemical behavior of paclitaxel drug was studied at a glassy carbon electrode in phosphate buffer solutions using cyclic and differential-pulse voltammetric techniques. The oxidation process was shown to be irreversible over the pH range (3.0-10.4) and was diffusion controlled. Effects of...
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| Format: | Book |
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Elsevier,
2014-02-01T00:00:00Z.
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| Summary: | The electrochemical behavior of paclitaxel drug was studied at a glassy carbon electrode in phosphate buffer solutions using cyclic and differential-pulse voltammetric techniques. The oxidation process was shown to be irreversible over the pH range (3.0-10.4) and was diffusion controlled. Effects of anodic peak potential (Ep), anodic peak current (Ipa), scan rate, pH, heterogeneous rate constant (k0), etc have been discussed. A possible electro-oxidation mechanism was proposed. An analytical method was developed for the determination of paclitaxel in phosphate buffer solution at pH = 7.0 as a supporting electrolyte. The anodic peak current varied linearly with paclitaxel concentration in the range 1.0 × 10−6 M to 1.0 × 10−5 M with a limit of detection (LOD) of 1.23 × 10−8 M and limit of quantification (LOQ) of 4.10 × 10−8 M. The proposed method was successfully applied to the determination of paclitaxel in pure and real samples. |
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| Item Description: | 1818-0876 10.1016/j.ajps.2013.11.007 |