Endogenous GABA Does Not Mediate the Inhibitory Effects of Gabapentin on Spinal Reflexes in Rats

The novel antiepileptic drug gabapentin was designed as a structural analog of γ-aminobutyric acid (GABA). However, its mechanism of action remains unclear. In the present study, we investigated the effect of gabapentin on spinal reflexes in anesthetized rats. The mono- and polysynaptic reflex poten...

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Autores principales: Shinobu Shimizu (Autor), Motoko Honda (Autor), Mitsuo Tanabe (Autor), Jun-Ichiro Oka (Autor), Hideki Ono (Autor)
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Publicado: Elsevier, 2004-01-01T00:00:00Z.
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