Pityriasis Rubra Pilar and hypothyroidism

Pityriasis Rubra Pilaris (PRP) is a chronic and rare papulosquamous disorder. Treatment of Pityriasis Rubra Pilaris is based on empiric evidence because of several doubts regarding its etiology and also because of its relative rarity, making randomized studies difficult to perform. Some factors sugg...

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Main Authors: Aline Martinez Franzotti (Author), Juliana Centofanti Dentello Avelar (Author), Thaís Abrão Cardoso (Author), Mario Cesar Pires (Author), Maria do Rosário Vidigal (Author)
Format: Book
Published: Sociedade Brasileira de Dermatologia, 2014-06-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Aline Martinez Franzotti  |e author 
700 1 0 |a Juliana Centofanti Dentello Avelar  |e author 
700 1 0 |a Thaís Abrão Cardoso  |e author 
700 1 0 |a Mario Cesar Pires  |e author 
700 1 0 |a Maria do Rosário Vidigal  |e author 
245 0 0 |a Pityriasis Rubra Pilar and hypothyroidism 
260 |b Sociedade Brasileira de Dermatologia,   |c 2014-06-01T00:00:00Z. 
500 |a 0365-0596 
500 |a 10.1590/abd1806-4841.20142994 
520 |a Pityriasis Rubra Pilaris (PRP) is a chronic and rare papulosquamous disorder. Treatment of Pityriasis Rubra Pilaris is based on empiric evidence because of several doubts regarding its etiology and also because of its relative rarity, making randomized studies difficult to perform. Some factors suggest that the metabolism of vitamin A is involved in pathogenesis. We report a case of Pityriasis Rubra Pilaris associated with autoimmune hypothyroidism which presented rapid and complete response after thyroid hormone replacement, without any association with other systemic treatment. In literature there are only three other reports of significant improvement of the lesions after hormonal correction. Deficiency of thyroid hormone inhibits the conversion of carotene into vitamin A, which would be responsible for the occurrence of Pityriasis Rubra Pilaris in this patient. 
546 |a EN 
546 |a PT 
690 |a Hypothyroidism 
690 |a Pityriasis rubra pilaris 
690 |a Therapeutics 
690 |a Dermatology 
690 |a RL1-803 
655 7 |a article  |2 local 
786 0 |n Anais Brasileiros de Dermatologia, Vol 89, Iss 3, Pp 497-500 (2014) 
787 0 |n http://www.scielo.br/pdf/abd/v89n3/0365-0596-abd-89-03-0497.pdf 
787 0 |n http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000300497&tlng=en 
787 0 |n https://doaj.org/toc/0365-0596 
856 4 1 |u https://doaj.org/article/dce8dcc1eb4a4cacab3bbdbdc81b37e1  |z Connect to this object online.