Fabrication of multiwalled carbon nanotube-surfactant modified sensor for the direct determination of toxic drug 4-aminoantipyrine
A multi-walled carbon nanotube (MWCNT)-cetyltrimethylammonium bromide (CTAB) surfactant composite modified glassy carbon electrode (GCE) was developed as a novel system for the determination of 4-aminoantipyrine(AAP). The oxidation process was irreversible over the pH range studied and exhibited a d...
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Elsevier,
2015-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_dce91babbc3d4aa08de1bcc6b349ed50 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Jayant I. Gowda |e author |
| 700 | 1 | 0 | |a Arunkumar T. Buddanavar |e author |
| 700 | 1 | 0 | |a Sharanappa T. Nandibewoor |e author |
| 245 | 0 | 0 | |a Fabrication of multiwalled carbon nanotube-surfactant modified sensor for the direct determination of toxic drug 4-aminoantipyrine |
| 260 | |b Elsevier, |c 2015-08-01T00:00:00Z. | ||
| 500 | |a 2095-1779 | ||
| 500 | |a 10.1016/j.jpha.2015.01.001 | ||
| 520 | |a A multi-walled carbon nanotube (MWCNT)-cetyltrimethylammonium bromide (CTAB) surfactant composite modified glassy carbon electrode (GCE) was developed as a novel system for the determination of 4-aminoantipyrine(AAP). The oxidation process was irreversible over the pH range studied and exhibited a diffusion controlled behavior. All experimental parameters were optimized. The combination of MWCNT-CTAB endows the biosensor with large surface area, good biological compatibility, electricity and stability, high selectivity and sensitivity. MWCNT-CTAB/GCE electrode gave a linear response for AAP from 5.0Ã10â9 to 4.0Ã10â8Â M with a detection limit of 1.63Ã10â10Â M. The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present electrochemical sensor based on the MWCNT-CTAB/GCE electrode was applied to the determination of AAP in real samples. Keywords: Voltammetry, Modified electrode, Diffusion controlled, 4-aminoantipyrine, Pharmacokinetic study | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmaceutical Analysis, Vol 5, Iss 4, Pp 231-238 (2015) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S209517791500012X | |
| 787 | 0 | |n https://doaj.org/toc/2095-1779 | |
| 856 | 4 | 1 | |u https://doaj.org/article/dce91babbc3d4aa08de1bcc6b349ed50 |z Connect to this object online. |