Fabrication of multiwalled carbon nanotube-surfactant modified sensor for the direct determination of toxic drug 4-aminoantipyrine

A multi-walled carbon nanotube (MWCNT)-cetyltrimethylammonium bromide (CTAB) surfactant composite modified glassy carbon electrode (GCE) was developed as a novel system for the determination of 4-aminoantipyrine(AAP). The oxidation process was irreversible over the pH range studied and exhibited a d...

Full description

Saved in:
Bibliographic Details
Main Authors: Jayant I. Gowda (Author), Arunkumar T. Buddanavar (Author), Sharanappa T. Nandibewoor (Author)
Format: Book
Published: Elsevier, 2015-08-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_dce91babbc3d4aa08de1bcc6b349ed50
042 |a dc 
100 1 0 |a Jayant I. Gowda  |e author 
700 1 0 |a Arunkumar T. Buddanavar  |e author 
700 1 0 |a Sharanappa T. Nandibewoor  |e author 
245 0 0 |a Fabrication of multiwalled carbon nanotube-surfactant modified sensor for the direct determination of toxic drug 4-aminoantipyrine 
260 |b Elsevier,   |c 2015-08-01T00:00:00Z. 
500 |a 2095-1779 
500 |a 10.1016/j.jpha.2015.01.001 
520 |a A multi-walled carbon nanotube (MWCNT)-cetyltrimethylammonium bromide (CTAB) surfactant composite modified glassy carbon electrode (GCE) was developed as a novel system for the determination of 4-aminoantipyrine(AAP). The oxidation process was irreversible over the pH range studied and exhibited a diffusion controlled behavior. All experimental parameters were optimized. The combination of MWCNT-CTAB endows the biosensor with large surface area, good biological compatibility, electricity and stability, high selectivity and sensitivity. MWCNT-CTAB/GCE electrode gave a linear response for AAP from 5.0Ã10â9 to 4.0Ã10â8 M with a detection limit of 1.63Ã10â10 M. The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present electrochemical sensor based on the MWCNT-CTAB/GCE electrode was applied to the determination of AAP in real samples. Keywords: Voltammetry, Modified electrode, Diffusion controlled, 4-aminoantipyrine, Pharmacokinetic study 
546 |a EN 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Journal of Pharmaceutical Analysis, Vol 5, Iss 4, Pp 231-238 (2015) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S209517791500012X 
787 0 |n https://doaj.org/toc/2095-1779 
856 4 1 |u https://doaj.org/article/dce91babbc3d4aa08de1bcc6b349ed50  |z Connect to this object online.