The effect of age on the CD16-positive cell count in human male blood

• Main Authors: Elsayed S Hamed (Author), Esam O Kamel (Author), Mohammad A Kasem (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1687-1693; 10.4103/AZMJ.AZMJ_84_19
• Keywords: blood; cd16+ve cells; human male; Internal medicine; RC31-1245
• Source: Al-Azhar Assiut Medical Journal, Vol 17, Iss 2, Pp 207-214 (2019)

Background Immuno-senescence is a process that affects all cell components of the immune system. Age-associated changes have been demonstrated in different aspects of the innate immunity system, including natural killer cells, neutrophils, and monocytes. Aim To identify and compare the effect of aging on the number of CD16+ve cells in the blood among different age groups of Egyptian human males. Patients and methods A total of 40 male donors (under legal consents) were classified into four groups. Each group involved 10 individuals. Group 1 individuals aged from 5 to 10 years, group 2 individuals aged from 15 to 25 years, group 3 individuals aged 30-40 years, whereas group 4 individuals aged from 50 to 60 years. Samples were obtained from each donor and divided into two parts. One part was subjected to complete blood counting and the other part was investigated by immunohistochemistry to detect CD16+ve cells. The collected data were tabulated and statistically analyzed by analysis of variance test using SPSS program. Results Our results showed a high significant difference among age groups regarding CD16+ve cell count, with higher count in group 4. Conclusion We can conclude that the number of CD16-positive cells is directly proportional to the advancement of age in human males. This increase possibly represents an immune response against the abnormal products of aging.