Potential role of odontoblasts in the innate immune response of the dental pulp

• Main Author: Tetiana Haniastuti (Author)
• Format: Book
• Published: Universitas Airlangga, 2008-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<span style="font-family: Tribune-Bold; font-size: 10pt; color: #201d1e; font-style: normal; font-variant: normal;"><strong>Background</strong><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>: Odontoblasts are the cells lining of tooth's hard structure at the dentin-pulp border, which become the first cells </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>encountered oral microorganisms entering dentin. However, they do not only form a physical barrier by producing dentin, but also </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>provide an innate immune barrier for the tooth. </em><span style="font-family: Tribune-Bold; font-size: 10pt; color: #201d1e; font-style: normal; font-variant: normal;"><strong>Purpose</strong><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>: The aim of this review was to discuss the potential role of odontoblasts in </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>the innate immune response of the dental pulp. </em><span style="font-family: Tribune-Bold; font-size: 10pt; color: #201d1e; font-style: normal; font-variant: normal;"><strong>Reviews</strong><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>: Recent studies have proven that odontoblasts express toll-like receptors, and </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>capable of producing chemokines (i.e. IL-8, CCL2, CXCL2, and CXCL10), and cytokines (IL-1</em><span style="font-family: Symbol; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;">β <span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>and TNF-</em><span style="font-family: Symbol; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;">α<span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>) following lipopolysacharide </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>exposure. Thereby odontoblasts are actively participating in the recruitment of immune cells in response to caries-derived bacterial </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>products. Furthermore, odontoblasts also produce antimicrobial peptides (hBD-1, hBD-2, and hBD-3), and transform growth factor </em><span style="font-family: Symbol; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;">β <span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>that induce antimicrobial and anti-inflammatory activities. </em><span style="font-family: Tribune-Bold; font-size: 10pt; color: #201d1e; font-style: normal; font-variant: normal;"><strong>Conclusion</strong><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>: The presence of those innate immune molecules indicates </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #201d1e; font-style: normal; font-variant: normal;"><em>that the nonspecific, natural, and rapidly acting defense may also be an important function of odontoblasts.</em></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span>

Item Description

1978-3728
2442-9740
10.20473/j.djmkg.v41.i3.p142-146