Protective Effects of <i>Dendropanax morbifera</i> against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy

• Main Authors: Ji Su Kim (Author), Kyeong Seok Kim (Author), Ji Yeon Son (Author), Hae Ri Kim (Author), Jae Hyeon Park (Author), Su Hyun Lee (Author), Da Eun Lee (Author), In Su Kim (Author), Kwang Youl Lee (Author), Byung Mu Lee (Author), Jong Hwan Kwak (Author), Hyung Sik Kim (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2076-3921; 10.3390/antiox8080256
• Keywords: cisplatin; <i>Dendropanax morbifera</i>; renoprotective effect; antioxidants; chemotherapy; xenograft model; Therapeutics. Pharmacology; RM1-950
• Source: Antioxidants, Vol 8, Iss 8, p 256 (2019)

Use of the chemotherapeutic agent cisplatin (CDDP) in cancer patients is limited by the occurrence of acute kidney injury (AKI); however, no protective therapy is available. We aimed to investigate the renoprotective effects of <i>Dendropanax morbifera</i> water extract (DM) on CDDP-induced AKI. Male Sprague-Dawley rats (six animals/group) received: Vehicle (control); CDDP (6 mg/kg, intraperitoneally (i.p.); DM (25 mg/kg, oral); or DM + CDDP injection. CDDP treatment significantly increased blood urea nitrogen (BUN), serum creatinine (sCr), and pro-inflammatory cytokines (IL-6 and TNF-&#945;), and severely damaged the kidney architecture. Urinary excretion of protein-based AKI biomarkers also increased in the CDDP-treated group. In contrast, DM ameliorated CDDP-induced AKI biomarkers. It markedly protected against CDDP-induced oxidative stress by increasing the activity of endogenous antioxidants and reducing the levels of pro-inflammatory cytokines (IL-6 and TNF-&#945;). The protective effect of DM in the proximal tubules was evident upon histopathological examination. In a tumor xenograft model, administration of DM enhanced the chemotherapeutic activity of CDDP and exhibited renoprotective effects against CDDP-induced nephrotoxicity without altering chemotherapeutic efficacy. Our data demonstrate that DM may be an adjuvant therapy with CDDP in solid tumor patients to preserve renal function.