Cerebral Intraventricular Hemorrhage and Interleukin-6 in Preterm Neonates

Background: Intraventricular hemorrhage (IVH) in preterm neonates is a serious problem in neonatal intensive care units (NICU) worldwide. IVH is reported in approximately 60-70% of very-low-birth-weight (VLBW) neonates. The present study aimed to assess the association of IVH with neonatal character...

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Main Authors: Mahnaz Fouladinejad (Author), Hadi Khorsand Zak (Author), Shahin SHirvani (Author), Mahsa Besharat (Author), Ehsan Alaee (Author)
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Published: Mashhad University of Medical Sciences, 2020-05-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Mahnaz Fouladinejad  |e author 
700 1 0 |a Hadi Khorsand Zak  |e author 
700 1 0 |a Shahin SHirvani  |e author 
700 1 0 |a Mahsa Besharat  |e author 
700 1 0 |a Ehsan Alaee  |e author 
245 0 0 |a Cerebral Intraventricular Hemorrhage and Interleukin-6 in Preterm Neonates 
260 |b Mashhad University of Medical Sciences,   |c 2020-05-01T00:00:00Z. 
500 |a 2251-7510 
500 |a 2322-2158 
500 |a 10.22038/ijn.2020.41572.1685 
520 |a Background: Intraventricular hemorrhage (IVH) in preterm neonates is a serious problem in neonatal intensive care units (NICU) worldwide. IVH is reported in approximately 60-70% of very-low-birth-weight (VLBW) neonates. The present study aimed to assess the association of IVH with neonatal characteristics and serum markers, such as serum Interleukin-6 (IL-6) level, in preterm neonates in an academic hospital in the Northeast of Iran.<br />Methods: In this cross-sectional study, a number of 71 VLBW preterm neonates (≤34 weeks of gestational age (GA), birth weight (BW) ≤1500g) were examined regarding the evidence of IVH up to the 40th week of GA in Gorgan, Northeast of Iran. The serum interleukin-6 (IL-6) level was measured within the first 12 hours of lifebirth. The association among the variables was analyzed in SPSS software (version 16) using the chi-square test.<br />Results: Out of 56 preterm neonates who survived until the 40th week, 15 (26.8%) cases demonstrated evidence of IVH at discharge, they had a significantly lower GA (29.04±2 weeks vs. 30.44±1.7 weeks; P=0.003) and BW (1075.43±208 kg vs. 1251.6±199.4 kg; P=0.001), as compared to 41(73.2%) newborns with no IVH. Preterm neonates with IVH had a significantly higher IL-6 serum level, as compared to those without IVH (224±210 pg/ml vs. 91.93±138 pg/ml; P=0.035).<br />Conclusion: As evidenced by the obtained result, low birth weight and premature birth could be serious risk factors for the development of IVH. Furthermore, IL-6 concentration may play a pivotal role in the occurrence of IVH. 
546 |a EN 
690 |a cerebral intraventricular hemorrhage 
690 |a interleukin-6 
690 |a premature birth 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Iranian Journal of Neonatology, Vol 11, Iss 2, Pp 10-13 (2020) 
787 0 |n http://ijn.mums.ac.ir/article_15630_1b59461087182c50c46693129b18e277.pdf 
787 0 |n https://doaj.org/toc/2251-7510 
787 0 |n https://doaj.org/toc/2322-2158 
856 4 1 |u https://doaj.org/article/dd69f93681d3486bacbc79c5d03214c1  |z Connect to this object online.