DoE-Based Design of a Simple but Efficient Preparation Method for a Non-Effervescent Gastro-Retentive Floating Tablet Containing Metformin HCl

• Hauptverfasser: Byungsuk Kim (Verfasst von), Youngjoo Byun (Verfasst von), Eun Hee Lee (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2021-08-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

A sustained-release non-effervescent floating matrix tablet was prepared using a simple and efficient direct compression of spray-dried granules containing metformin hydrochloride and cetyl alcohol with hydroxypropyl methylcellulose K15M (HPMC K15M). The design of experiments was employed to explore...