DoE-Based Design of a Simple but Efficient Preparation Method for a Non-Effervescent Gastro-Retentive Floating Tablet Containing Metformin HCl

• Váldodahkkit: Byungsuk Kim (Dahkki), Youngjoo Byun (Dahkki), Eun Hee Lee (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2021-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

A sustained-release non-effervescent floating matrix tablet was prepared using a simple and efficient direct compression of spray-dried granules containing metformin hydrochloride and cetyl alcohol with hydroxypropyl methylcellulose K15M (HPMC K15M). The design of experiments was employed to explore...