Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs

• Main Authors: Florian Pöstges (Author), Kevin Kayser (Author), Jan Appelhaus (Author), Marius Monschke (Author), Michael Gütschow (Author), Christian Steinebach (Author), Karl G. Wagner (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PROteolysis TArgeting Chimaeras (PROTACs) offer new opportunities in modern medicine by targeting proteins that are undruggable to classic inhibitors. However, due to their hydrophobic structure, PROTACs typically suffer from low solubility, and oral bioavailability remains challenging. At the same...