Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs
PROteolysis TArgeting Chimaeras (PROTACs) offer new opportunities in modern medicine by targeting proteins that are undruggable to classic inhibitors. However, due to their hydrophobic structure, PROTACs typically suffer from low solubility, and oral bioavailability remains challenging. At the same...
Saved in:
Main Authors: | Florian Pöstges (Author), Kevin Kayser (Author), Jan Appelhaus (Author), Marius Monschke (Author), Michael Gütschow (Author), Christian Steinebach (Author), Karl G. Wagner (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2023-01-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Boost of solubility and supersaturation of celecoxib via synergistic interactions of methacrylic acid-ethyl acrylate copolymer (1:1) and hydroxypropyl cellulose in ternary amorphous solid dispersions
by: Florian Pöstges, et al.
Published: (2022) -
Processing of Polyvinyl Acetate Phthalate in Hot-Melt Extrusion-Preparation of Amorphous Solid Dispersions
by: Marius Monschke, et al.
Published: (2020) -
Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A
by: Anna K. Krome, et al.
Published: (2020) -
Overcoming Obstacles to Broader Impacts Implementation
by: Alisa Zornig Gura, et al.
Published: (2024) -
Impact of HPMCAS on the Dissolution Performance of Polyvinyl Alcohol Celecoxib Amorphous Solid Dispersions
by: Marius Monschke, et al.
Published: (2020)