Anti-Fibrotic Effects of Low Toxic Microcystin-RR on Bleomycin-Induced Pulmonary Fibrosis: A Comparison with Microcystin-LR
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial pulmonary disease characterized with radiographically evident pulmonary infiltrates and extracellular matrix deposition with limited treatment options. We previously described that microcystin-LR (MC-LR) reduces transforming g...
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Frontiers Media S.A.,
2021-06-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Jie Wang |e author |
| 700 | 1 | 0 | |a Jie Wang |e author |
| 700 | 1 | 0 | |a Yan Ren |e author |
| 700 | 1 | 0 | |a Yan Ren |e author |
| 700 | 1 | 0 | |a Xiufen Zheng |e author |
| 700 | 1 | 0 | |a Jiaqi Kang |e author |
| 700 | 1 | 0 | |a Jiaqi Kang |e author |
| 700 | 1 | 0 | |a Zhenqian Huang |e author |
| 700 | 1 | 0 | |a Zhenqian Huang |e author |
| 700 | 1 | 0 | |a Lizhi Xu |e author |
| 700 | 1 | 0 | |a Lizhi Xu |e author |
| 700 | 1 | 0 | |a Yaping Wang |e author |
| 700 | 1 | 0 | |a Yaping Wang |e author |
| 245 | 0 | 0 | |a Anti-Fibrotic Effects of Low Toxic Microcystin-RR on Bleomycin-Induced Pulmonary Fibrosis: A Comparison with Microcystin-LR |
| 260 | |b Frontiers Media S.A., |c 2021-06-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2021.675907 | ||
| 520 | |a Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial pulmonary disease characterized with radiographically evident pulmonary infiltrates and extracellular matrix deposition with limited treatment options. We previously described that microcystin-LR (MC-LR) reduces transforming growth factor (TGF)-β1/Smad signaling and ameliorates pulmonary fibrosis in bleomycin (BLM)-induced rat models. In the present study, we further demonstrate that microcystin-RR (MC-RR), an MC congener with lower toxicity than MC-LR, exerted an anti-fibrotic effect on BLM-induced pulmonary fibrosis rodent models and compared it with MC-LR. Our data show that MC-RR treatment attenuated BLM-associated pulmonary inflammation and collagen deposition in both therapeutic and preventive models. MC-RR reduced the expression of fibrotic markers, including vimentin, α-smooth muscle actin, collagen 1α1, and fibronectin, in rat pulmonary tissues. Furthermore, the core features of BLM-induced pulmonary fibrotic lesions were better alleviated by MC-RR than by MC-LR. MC-RR treatment substantially decreased the number of pulmonary M2 macrophages. In vitro, MC-RR attenuated the epithelial-mesenchymal transition and fibroblast-myofibroblast transition triggered by M2 macrophages. Therefore, we highlight MC-RR as a promising molecule for developing therapeutic and prophylactic strategies against IPF, a refractory lung disease. | ||
| 546 | |a EN | ||
| 690 | |a pulmonary fibrosis | ||
| 690 | |a microcystin-RR | ||
| 690 | |a microcystin-LR | ||
| 690 | |a macrophages | ||
| 690 | |a bleomycin | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 12 (2021) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2021.675907/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/dda205ddc7d743f2b6089bdd4a9a4c28 |z Connect to this object online. |