Nutritional stress targets LeishIF4E-3 to storage granules that contain RNA and ribosome components in Leishmania.
Leishmania parasites lack pathways for de novo purine biosynthesis. The depletion of purines induces differentiation into virulent metacyclic forms. In vitro, the parasites can survive prolonged periods of purine withdrawal changing their morphology to long and slender cells with an extended flagell...
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| Main Authors: | , , |
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| Format: | Book |
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Public Library of Science (PLoS),
2019-03-01T00:00:00Z.
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