Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies
The purpose of this study was to compare the pharmacokinetic and pharmacodynamic parameters of three formulations of a new drug on the basis of plasmid DNA pCIGF for regenerative gene therapy damage the surface of human tissues of various etiologies. Preclinical study of the pharmacological properti...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
LLC "Publisher OKI",
2013-04-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | The purpose of this study was to compare the pharmacokinetic and pharmacodynamic parameters of three formulations of a new drug on the basis of plasmid DNA pCIGF for regenerative gene therapy damage the surface of human tissues of various etiologies. Preclinical study of the pharmacological properties of the drug and drug safety carried out in mice, which was administered once and twice. Introduction of liquid and lyophilized forms of the drug was carried out by intramuscular injection, topically applied gel form. Analyzed various organs: brain, heart, blood, lung, liver, kidney, spleen, muscle for the presence of plasmid depending on the time after administration. |
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| Item Description: | 2587-7836 2686-8830 |