Secondary syphilis associated crescentic glomerulonephritis: A case report
Introduction: Syphilis is a sexually transmitted disease caused by the bacterium Treponema Pallidum and has a diverse clinical presentation, including nephropathies, the most common of which is membranous nephropathy. Crescentic glomerulonephritis is not typically considered to be a manifestation of...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Elsevier,
2021-11-01T00:00:00Z.
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| Summary: | Introduction: Syphilis is a sexually transmitted disease caused by the bacterium Treponema Pallidum and has a diverse clinical presentation, including nephropathies, the most common of which is membranous nephropathy. Crescentic glomerulonephritis is not typically considered to be a manifestation of Syphilis associated renal disease. Case presentation: Here we describe an unusual case of crescentic glomerulonephritis associated with secondary syphilis resulting in a rapidly progressing glomerulonephritis presentation requiring hemodialysis. The patient was treated with Penicillin G and intravenous solumedrol. The patient's kidney function recovered and several months after presentation the patient was asymptomatic off hemodialysis with a serum creatinine of 1.54 mg/dL. Discussion/conclusion: Secondary syphilis rarely presents with rapidly progressive glomerulonephritis. This report is only the third such case reported to date of a diffuse necrotizing/crescentic glomerulonephritis resulting from a syphilis infection. As syphilis is on the rise, this report highlights an important differential diagnostic consideration for any necrotizing/crescentic glomerulonephritis. |
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| Item Description: | 2772-736X 10.1016/j.hpr.2021.300563 |