An accelerated hypofractionated radiotherapy regimen in patients after organ-sparing surgery for stages I-IIA breast cancer

• Main Authors: I. A. Gladilina (Author), L. Ya. Klepper (Author), Yu. V. Efimkina (Author), I. V. Vysotskaya (Author), A. V. Petrovskiy (Author), O. V. Kozlov (Author), M. V. Chernykh (Author), E. Yu. Voronchikhina (Author), E. S. Makarov (Author), A. V. Ivanova (Author)
• Format: Book
• Published: ABV-press, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1994-4098; 1999-8627; 10.17650/1994-4098-2016-12-3-17-22
• Keywords: breast cancer; radiotherapy; organ-sparing surgery; local recurrences; Gynecology and obstetrics; RG1-991
• Source: Опухоли женской репродуктивной системы, Vol 12, Iss 3, Pp 17-22 (2016)

Objective: to assess the results of accelerated hypofractionated radiotherapy and to comparatively analyze it with the standard radiotherapy in patients with stages I-IIA breast cancer (BC) after organ-sparing surgery.Materials and methods. A total of 203 patients with stages I-IIA BC underwent radiotherapy after organ-sparing surgery. A control group of 91 patients received the standard radiotherapy (the single focal dose (SFD) was 2 Gy 5 times a week, 25 fractions; the total focal dose (TFD) was 50 Gy for 5 weeks). A study group of 112 patients had accelerated hypofractionated radiotherapy (SFD 3 Gy 5 times a week, 13 fractions; TFD 39 Gy for 2.3 weeks).Results. Local recurrences were not detected in any patient after the hypofractionated radiotherapy regimen and were diagnosed in 3.3 % of the patients after the standard regimen. There were no statistically significant differences between the groups in 5-year overall and relapsefree survival rates. Further observation revealed a statistically significant difference in 6-year overall survival rates in the study and control groups: 99.1 and 70.4 %, respectively (p ≤ 0.046). The 6-year relapse-free survival rates in patients who had received the accelerated hypo-fractionated radiotherapy regimen were also significantly higher than in those who had the standard radiotherapy regimen: 97.9 and 71.3 %, respectively (p ≤ 0.043). The rate of post-radiation normal tissue damages after the hypofractionated radiotherapy regimen was significantly lower (15.2 %) than that after the standard regimen (27.5 %). Good and excellent cosmetic results of treatment were achieved in most (95.1 %) patients and did not differ in their frequency after different radiotherapy regimens.Conclusion. The accelerated hypofractionated radiotherapy regimen showed a high efficiency and a favorable toxicity profile in patients with stages I-IIA BC.