<it>HOX </it>genes in ovarian cancer
<p>Abstract</p> <p>The <it>HOX </it>genes are a family of homeodomain-containing transcription factors that determine cellular identity during development. Here we review a number of recent studies showing that <it>HOX </it>genes are strongly expressed in ov...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
BMC,
2011-09-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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| Summary: | <p>Abstract</p> <p>The <it>HOX </it>genes are a family of homeodomain-containing transcription factors that determine cellular identity during development. Here we review a number of recent studies showing that <it>HOX </it>genes are strongly expressed in ovarian cancer, and that in some cases the expression of specific <it>HOX </it>genes is sufficient to confer a particular identity and phenotype upon cancer cells. We also review the recent advances in elucidating the different functions of <it>HOX </it>genes in ovarian cancer. A literature search was performed using the search terms <it>HOX </it>genes (including specific <it>HOX </it>genes), ovarian cancer and oncogenesis. Articles were accessed through searches performed in ISI Web of Knowledge, PubMed and ScienceDirect. Taken together, these studies have shown that <it>HOX </it>genes play a role in the oncogenesis of ovarian cancer and function in the inhibition of apoptosis, DNA repair and enhanced cell motility. The function of <it>HOX </it>genes in ovarian cancer oncogenesis supports their potential role as prognostic and diagnostic markers, and as therapeutic targets in this disease.</p> |
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| Item Description: | 10.1186/1757-2215-4-16 1757-2215 |