Predictable risk factors and clinical courses for prolonged transient tachypnea of the newborn

Purpose : Transient tachypnea of the newborn (TTN) is usually benign and improves within 72 hours. However, it can also progress to prolonged tachypnea over 72 hours, profound hypoxemia, respiratory failure, and even death. The aim of this study is to find predictable risk factors and describe the c...

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Main Authors: Ji Young Chang (Author), Chang Ryul Kim (Author), Ellen A Kim (Author), Ki Soo Kim (Author)
Format: Book
Published: Korean Pediatric Society, 2010-03-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Ji Young Chang  |e author 
700 1 0 |a Chang Ryul Kim  |e author 
700 1 0 |a Ellen A Kim  |e author 
700 1 0 |a Ki Soo Kim  |e author 
245 0 0 |a Predictable risk factors and clinical courses for prolonged transient tachypnea of the newborn 
260 |b Korean Pediatric Society,   |c 2010-03-01T00:00:00Z. 
500 |a 10.3345/kjp.2010.53.3.349 
500 |a 1738-1061 
500 |a 2092-7258 
520 |a Purpose : Transient tachypnea of the newborn (TTN) is usually benign and improves within 72 hours. However, it can also progress to prolonged tachypnea over 72 hours, profound hypoxemia, respiratory failure, and even death. The aim of this study is to find predictable risk factors and describe the clinical courses and outcomes of prolonged TTN (PTTN). Methods : The medical records of 107 newborns, &amp&#59;gt&#59;35+0 weeks of gestational age with TTN, who were admitted to the NICU at Seoul Asan Medical Center from January 2001 to September 2007 were reviewed. They were divided into 2 groups based on duration of tachypnea. PTTN was defined as tachypnea ?#247;2 hours of age, and simple TTN (STTN) as tachypnea &amp&#59;lt&#59;72 hours of age. We randomly selected 126 healthy-term newborns as controls. We evaluated neonatal and maternal demographic findings, and various clinical factors. Results : Fifty-five infants (51%) with total TTN were PTTN. PTTN infants had grunting, tachypnea &amp&#59;gt&#59;90/min, FiO2 &amp&#59;gt&#59;0.4, and required ventilator care more frequently than STTN infants. PTTN had lower level of serum total protein and albumin than STTN. The independent predictable risk factors for PTTN were grunting, maximal respiration rate &amp&#59;gt&#59;90/min, and FiO2 &amp&#59;gt&#59;0.4 within 6 hours of life. Conclusion : When a newborn has grunting, respiration rate &amp&#59;gt&#59;90/min, and oxygen requirement &amp&#59;gt&#59;0.4 of FiO2 within 6 hours of life, the infant is at high risk of having persistent tachypnea ?#247;2 hours. We need further study to find the way to reduce PTTN. 
546 |a EN 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Korean Journal of Pediatrics, Vol 53, Iss 3, Pp 349-357 (2010) 
787 0 |n http://www.kjp.or.kr/upload/2010530311-20100456154656.PDF 
787 0 |n https://doaj.org/toc/1738-1061 
787 0 |n https://doaj.org/toc/2092-7258 
856 4 1 |u https://doaj.org/article/de9f23c0af5b4dfb94a4d06b001d2c60  |z Connect to this object online.