Deep venous thrombosis in a patient undergoing In-vitrofertilization with oocyte donation

• Main Authors: Nalini Mahajan (Author), Padmaja Naidu (Author), Shalu Gupta (Author), Kumkum Rani (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0974-1208; 1998-4766; 10.4103/0974-1208.165150
• Keywords: Frozen embryo transfer; hormone replacement therapy; in-vitrofertilization-oocyte donation; venous thrombo-embolism; Gynecology and obstetrics; RG1-991
• Source: Journal of Human Reproductive Sciences, Vol 8, Iss 3, Pp 182-185 (2015)

Deep venous thrombosis (DVT) has been reported extensively following ovarian hyperstimulation syndrome during in-vitrofertilization (IVF). Pregnancy per seincreases the risk of DVT due to a hypercoagulable state. The long-term use of hormone replacement therapy (HRT) is another critical factor associated with DVT in women. However, an association between the short-term use of HRT in oocyte donation (OD) cycles and DVT has not yet been reported. We present a case of 43-year-old woman who developed DVT after IVF-OD. DVT was diagnosed at 7 weeks of pregnancy and was managed with low-molecular-weight heparin. We suggest that even a short-term use of HRT should be considered a risk factor for DVT especially in the presence of additional risk factors such as obesity. The patient had an uneventful recovery and delivered three healthy though preterm babies.