Distribution of DJ-1, Parkinson's Disease-Related Protein PARK7, and Its Alteration in 6-Hydroxydopamine-Treated Hemiparkinsonian Rat Brain
DJ-1 has multiple functions and its dysfunction may be linked to the onset of familial Parkinson's disease PARK7. However, the function and distribution of DJ-1 is unclear. In this study, we determined DJ-1 distribution and change after intranigral injection of 6-hydroxydopamine (6-OHDA). Altho...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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Elsevier,
2006-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | DJ-1 has multiple functions and its dysfunction may be linked to the onset of familial Parkinson's disease PARK7. However, the function and distribution of DJ-1 is unclear. In this study, we determined DJ-1 distribution and change after intranigral injection of 6-hydroxydopamine (6-OHDA). Although distribution of DJ-1 immunoreactivity was not changed in cerebral cortex and striatum, 6-OHDA caused increase of DJ-1 in the particulate fraction and decrease in the cytosolic fraction in substantia nigra. At that time, DJ-1 shifted to acid forms. These results suggest that distributional changes, translocation, and acidic shift of DJ-1 may be compensatory responses to protect against 6-OHDA-induced oxidative stress. Keywords:: DJ-1, 6-hydroxydopamine, Parkinson's disease |
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| Item Description: | 1347-8613 10.1254/jphs.SC0060098 |