A case of gemcitabine-induced thrombotic microangiopathy in a urothelial tumor patient with a single kidney

Thrombotic microangiopathy (TMA) is a rare complication of gemcitabine treatment. A 55-year-old man with a history of urothelial cancer underwent right ureteronephrectomy and palliative chemotherapy. The patient presented with dyspnea, generalized edema with foamy urine, and new-onset hypertension w...

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Main Authors: Hyunjin Ryu (Author), Eunjeong Kang (Author), Seokwoo Park (Author), Sehoon Park (Author), Kyoungbun Lee (Author), Kwon Wook Joo (Author), Hajeong Lee (Author)
Format: Book
Published: The Korean Society of Nephrology, 2015-12-01T00:00:00Z.
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100 1 0 |a Hyunjin Ryu  |e author 
700 1 0 |a Eunjeong Kang  |e author 
700 1 0 |a Seokwoo Park  |e author 
700 1 0 |a Sehoon Park  |e author 
700 1 0 |a Kyoungbun Lee  |e author 
700 1 0 |a Kwon Wook Joo  |e author 
700 1 0 |a Hajeong Lee  |e author 
245 0 0 |a A case of gemcitabine-induced thrombotic microangiopathy in a urothelial tumor patient with a single kidney 
260 |b The Korean Society of Nephrology,   |c 2015-12-01T00:00:00Z. 
500 |a 2211-9132 
500 |a 10.1016/j.krcp.2015.06.001 
520 |a Thrombotic microangiopathy (TMA) is a rare complication of gemcitabine treatment. A 55-year-old man with a history of urothelial cancer underwent right ureteronephrectomy and palliative chemotherapy. The patient presented with dyspnea, generalized edema with foamy urine, and new-onset hypertension with acute kidney injury (AKI). Although AKI with oliguria was evident, thrombocytopenia and hemolytic anemia were not overt. To determine the cause of rapidly progressive azotemia, kidney biopsy was performed despite a single kidney and revealed chronic TMA. Microangiopathic hemolytic anemia and thrombocytopenia developed after renal biopsy. Diagnosed as gemcitabine-induced TMA, gemcitabine cessation and active treatment including steroids, plasmapheresis, and rituximab were carried out, but the patient׳s condition progressed to a dialysis-dependent state. Gemcitabine-induced TMA is often difficult to diagnose because of its variable clinical course. Therefore, heightened awareness of this potentially lethal complication of gemcitabine is essential; renal biopsy may be helpful. 
546 |a EN 
546 |a KO 
690 |a Gemcitabine 
690 |a Thrombotic microangiopathy 
690 |a Urothelial carcinoma 
690 |a Internal medicine 
690 |a RC31-1245 
690 |a Specialties of internal medicine 
690 |a RC581-951 
655 7 |a article  |2 local 
786 0 |n Kidney Research and Clinical Practice, Vol 34, Iss 4, Pp 237-240 (2015) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S2211913215300127 
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856 4 1 |u https://doaj.org/article/df0dde09dcec4898a7b3b0ecb0b74c36  |z Connect to this object online.