Case Report: Trichosporon japonicum Fungemia in a Pediatric Patient With Refractory Acute B Cell Lymphoblastic Leukemia

• Main Authors: Sami Albitar-Nehme (Author), Marilena Agosta (Author), Agata Helena Kowalska (Author), Livia Mancinelli (Author), Manuela Onori (Author), Barbara Lucignano (Author), Giordana Mattana (Author), Francesco Quagliarella (Author), Maria Giuseppina Cefalo (Author), Pietro Merli (Author), Franco Locatelli (Author), Carlo Federico Perno (Author), Paola Bernaschi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Trichosporon japonicum is a very rare opportunistic yeast causing fungal disease in humans, especially in immunocompromised hosts. Here, we describe a new case of T. japonicum isolated from the blood of a pyrexial pediatric patient with refractory acute B cell lymphoblastic leukemia and acute respiratory distress. Prompt diagnosis through early clinical suspicion and appropriate molecular microbiology analysis allowed the yeast to be accurately identified at species level. Subsequent drug susceptibility testing and focused antifungal treatment with voriconazole and amphotericin B led to a complete clinical and mycological resolution of the infection, which represents the second successful case of T. japonicum bloodstream infection described in literature to date.

Item Description

2296-2360
10.3389/fped.2022.861476