Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent

• Main Authors: Ravikumar Ukawala (Author), Gautam Singhvi (Author), Suresh Jain (Author), Vipin Shukla (Author), Nilesh Yadav (Author), Sohiny Sharma (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of the present work was to design and evaluate the once daily sustained release matrix type gastro-retentive floating tablet of Quetiapine Fumarate base on hydrophilic matrices of HPMC, sodium CMC and Carbopol. Sodium bicarbonate was incorporated as a gas-generating agent to give buoyanc...