Sildenafil improves exercise capacity in patients with cystic fibrosis: a proof-of-concept clinical trial

• Những tác giả chính: Paula Rodriguez-Miguelez (Tác giả), Haruki Ishii (Tác giả), Nichole Seigler (Tác giả), Reva Crandall (Tác giả), Jeffrey Thomas (Tác giả), Caralee Forseen (Tác giả), Kathleen T. McKie (Tác giả), Ryan A. Harris (Tác giả)
• Định dạng: Sách
• Được phát hành: SAGE Publishing, 2019-11-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Background: Exercise intolerance is a common phenotype observed in patients with cystic fibrosis (CF). Treatment with sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, has previously been shown to improve exercise capacity (VO 2 peak) in other patient populations. Thus, the present study soug...