Antioxidant properties of some novel derivatives thiazolo[4,5-b] pyridine
The synthesis and determination of the antioxidant activity of some novel (5,7-dimethyl-2-oxo-thiazolo[4,5-b]pyridine-3-yl)-acetic acid hydrazide derivatives are described in this article. The transformation of the base heterocycle was carried out via the reactions of acylation, [2+3]cyclocondensati...
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| मुख्य लेखकों: | , , , , , , |
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| स्वरूप: | पुस्तक |
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Pensoft Publishers,
2019-12-01T00:00:00Z.
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| सारांश: | The synthesis and determination of the antioxidant activity of some novel (5,7-dimethyl-2-oxo-thiazolo[4,5-b]pyridine-3-yl)-acetic acid hydrazide derivatives are described in this article. The transformation of the base heterocycle was carried out via the reactions of acylation, [2+3]cyclocondensation, Knoevenagel condencation and alkylation for the purpose to obtain substances with a satisfactory pharmacological profile. Antioxidant activity of the synthesized compounds was evaluated in vitro by means of the scavenging metod effect on 2,2 diphenyl-1-picrylhydrazyl (DPPH) radicals. |
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| वस्तु वर्णन: | 10.3897/pharmacia.66.e36764 2603-557X |