Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

• المؤلفون الرئيسيون: Igor Mokrousov (مؤلف), Ivaylo Slavchev (مؤلف), Natalia Solovieva (مؤلف), Marine Dogonadze (مؤلف), Anna Vyazovaya (مؤلف), Violeta Valcheva (مؤلف), Aleksey Masharsky (مؤلف), Olesya Belopolskaya (مؤلف), Simeon Dimitrov (مؤلف), Viacheslav Zhuravlev (مؤلف), Isabel Portugal (مؤلف), João Perdigão (مؤلف), Georgi M. Dobrikov (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-09-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain <i>Mycobacterium tuberculosis<...