Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

• প্রধান লেখক: Igor Mokrousov (লেখক), Ivaylo Slavchev (লেখক), Natalia Solovieva (লেখক), Marine Dogonadze (লেখক), Anna Vyazovaya (লেখক), Violeta Valcheva (লেখক), Aleksey Masharsky (লেখক), Olesya Belopolskaya (লেখক), Simeon Dimitrov (লেখক), Viacheslav Zhuravlev (লেখক), Isabel Portugal (লেখক), João Perdigão (লেখক), Georgi M. Dobrikov (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2022-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain <i>Mycobacterium tuberculosis<...