Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

• Main Authors: Igor Mokrousov (Author), Ivaylo Slavchev (Author), Natalia Solovieva (Author), Marine Dogonadze (Author), Anna Vyazovaya (Author), Violeta Valcheva (Author), Aleksey Masharsky (Author), Olesya Belopolskaya (Author), Simeon Dimitrov (Author), Viacheslav Zhuravlev (Author), Isabel Portugal (Author), João Perdigão (Author), Georgi M. Dobrikov (Author)
• Format: Bog
• Udgivet: MDPI AG, 2022-09-01T00:00:00Z.
• Fag: article
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We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain <i>Mycobacterium tuberculosis<...