Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

• Hauptverfasser: Igor Mokrousov (Verfasst von), Ivaylo Slavchev (Verfasst von), Natalia Solovieva (Verfasst von), Marine Dogonadze (Verfasst von), Anna Vyazovaya (Verfasst von), Violeta Valcheva (Verfasst von), Aleksey Masharsky (Verfasst von), Olesya Belopolskaya (Verfasst von), Simeon Dimitrov (Verfasst von), Viacheslav Zhuravlev (Verfasst von), Isabel Portugal (Verfasst von), João Perdigão (Verfasst von), Georgi M. Dobrikov (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain <i>Mycobacterium tuberculosis<...