Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

• Κύριοι συγγραφείς: Igor Mokrousov (Συγγραφέας), Ivaylo Slavchev (Συγγραφέας), Natalia Solovieva (Συγγραφέας), Marine Dogonadze (Συγγραφέας), Anna Vyazovaya (Συγγραφέας), Violeta Valcheva (Συγγραφέας), Aleksey Masharsky (Συγγραφέας), Olesya Belopolskaya (Συγγραφέας), Simeon Dimitrov (Συγγραφέας), Viacheslav Zhuravlev (Συγγραφέας), Isabel Portugal (Συγγραφέας), João Perdigão (Συγγραφέας), Georgi M. Dobrikov (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2022-09-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain <i>Mycobacterium tuberculosis<...