Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

• Үндсэн зохиолчид: Igor Mokrousov (Зохиогч), Ivaylo Slavchev (Зохиогч), Natalia Solovieva (Зохиогч), Marine Dogonadze (Зохиогч), Anna Vyazovaya (Зохиогч), Violeta Valcheva (Зохиогч), Aleksey Masharsky (Зохиогч), Olesya Belopolskaya (Зохиогч), Simeon Dimitrov (Зохиогч), Viacheslav Zhuravlev (Зохиогч), Isabel Portugal (Зохиогч), João Perdigão (Зохиогч), Georgi M. Dobrikov (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2022-09-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain <i>Mycobacterium tuberculosis<...