Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

• Автори: Igor Mokrousov (Автор), Ivaylo Slavchev (Автор), Natalia Solovieva (Автор), Marine Dogonadze (Автор), Anna Vyazovaya (Автор), Violeta Valcheva (Автор), Aleksey Masharsky (Автор), Olesya Belopolskaya (Автор), Simeon Dimitrov (Автор), Viacheslav Zhuravlev (Автор), Isabel Portugal (Автор), João Perdigão (Автор), Georgi M. Dobrikov (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2022-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain <i>Mycobacterium tuberculosis<...