An evaluation of a supratherapeutic dose of inclisiran on cardiac repolarization in healthy volunteers: A phase I, randomized study

• Główni autorzy: David Kallend (Autor), Jay Mason (Autor), Patrick F. Smith (Autor), Michael J. Koren (Autor), Robert Stoekenbroek (Autor), YanLing He (Autor), Peter Wijngaard (Autor)
• Format: Książka
• Wydane: Wiley, 2022-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Inclisiran is a small interfering RNA molecule that has been shown to provide an effective and sustained reduction in low‐density lipoprotein cholesterol levels. This study aimed to determine whether a supratherapeutic dose of inclisiran affects cardiac repolarization and conduction in heal...