FDG-PET-CT as an early detection method for tuberculosis: a systematic review and meta-analysis

Abstract Tuberculosis (TB) causes major public health problems worldwide. Fighting TB requires sustained efforts in health prevention, diagnosis and treatment. Previous literature has shown that conventional diagnostic methods like X-ray and sputum microscopy often miss early or extrapulmonary TB du...

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Main Authors: Josef Yayan (Author), Kurt Rasche (Author), Karl-Josef Franke (Author), Wolfram Windisch (Author), Melanie Berger (Author)
Format: Book
Published: BMC, 2024-07-01T00:00:00Z.
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Summary:Abstract Tuberculosis (TB) causes major public health problems worldwide. Fighting TB requires sustained efforts in health prevention, diagnosis and treatment. Previous literature has shown that conventional diagnostic methods like X-ray and sputum microscopy often miss early or extrapulmonary TB due to their limited sensitivity. Blood tests, while useful, lack the anatomical detail needed for precise localization of TB lesions. A possible step forward in the fight against TB could be the use of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and Computed Tomography (CT). This meta-analysis discusses the current literature, including the methods, results and implications of using FDG-PET-CT in the early diagnosis of TB. Analysis of the studies showed that the sensitivity of FDG-PET-CT as a potential method for early detection of TB was 82.6%.
Item Description:10.1186/s12889-024-19495-6
1471-2458